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Centenarians have plasma MOTS-c levels resembling those of people decades younger, suggesting preserved mitochondrial signaling is a feature of exceptional aging
Future decision-making frameworks based on phenotype stratification and Bayesian integration should prioritize identifying who requires long-term maintenance versus a short-term window, and how to minimize the reproductive costs of post-discontinuation rebound
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Presented for research literature review only Chol M et al
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